Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin-nicotinamide cocrystal by solid-state NMR.

نویسندگان

  • Keisuke Maruyoshi
  • Dinu Iuga
  • Oleg N Antzutkin
  • Amjad Alhalaweh
  • Sitaram P Velaga
  • Steven P Brown
چکیده

Two-dimensional (1)H double-quantum and (14)N-(1)H & (1)H-(13)C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOH···N(arom) and CH(arom)···O=C hydrogen-bonding interactions in the solid-state structure of an indomethacin-nicotinamide cocrystal, thus additionally proving cocrystal formation.

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عنوان ژورنال:
  • Chemical communications

دوره 48 88  شماره 

صفحات  -

تاریخ انتشار 2012